Clinical Research IT Solutions

Electronic Data Collection (EDC)

Our system provides a wide range of web-based software products to support your clinical research study. It consists of a clinical trials management system (CTMS), a CRF/Form Designer for electronic data collection (EDC) and an electronic patient portal (ePRO).

The web-based CRF/Forms Designer is probably the most sophisticated forms designer available. It caters for the typical question types, and also has novel question types, like table-based questions (combination of text/radio/dropdown/checkbox/likert field questions in multiple fixed or dynamic rows), image mark, file upload and EEG node selection. Branching/skip rules can be implemented on individual questions, groups of questions and fields within table-based questions. And if you need a new feature or application, we can develop it for you!

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Subject enrolment
Activity tracking
CRF Forms Designer (sophisticated!)
Study Arms/Events/Participant Types
Specimen tracking
Participant scheduling
File Upload
Contacts & Meetings
Audit Trail
Study Dashboard
Multi-language Support
Patient Telephone Contact Log
Data Verification/Lock
Study-specific timezone
Pedigree Charting Tool
Export to GEDCOM format
ePRO (patient reported data)
Electronic Patient Diary
Data Extracts
SAS Extract File
Study Arm Randomization
Document Library
Protocol Design & Study Set-up
Two-factor Authentication
Chat/Message Board
Adverse Events
Links to PubMed and
Role-based Security
CRF version and data-edit history
No 3rd party license costs
Active Directory support
Data Warehouse
Data Management/ETL

CRF Question Types

Text field
Paragraph field (text box)
Radio button
Drop-down list
Check boxes
Likert scale (range or slider)
Visual Analogue Scale
File upload
1020 EEG
Image mark
Image display
Message box (alert)
Message text
ICD9 & ICD10
Horizontal line
Email CRF/form response
URL redirect
Grid/Matrix Questions (with multiple columns)
Grid/Matrix Questions (with dynamic rows)
Sections of questions
Duration question (e.g. age)
Happy-Sad face question
Pain-scale (with faces)
Concomitant Medication
And more...

VarTracker - Genetic Variant Tracker and Alerts

VarTracker is a web-based tool for retrieving information on genetic variants and generating alerts when variant data changes. The end-user can search for variants of interest based on a RefSeq ID and a cDNA change, and the tool will search and extract data from a variety of public databases, such as ClinVar, NCBI Gene, UniProt, dbSNP, NCBI Books, PubMed, MalaCard, MyVariant, gnomAD, ExAC, Mutalyze and ENSEMBL. The system will then re-check these variants every 24 hours to see if any variant information has changed, and will alert the end-user of these changes.

Artificial Intelligence

CLIRINX provides sophisticated Artificial Intelligence (AI) tools for clinical research. Expert systems can be used to help with decision-making and solve complex problems in medical research. AI tools are computer applications that combine software and specialized information to imitate expert human reasoning and advice. We also have a knowledge base (KB) editor that allows you to define and store complex structured and unstructured information about a specific area of knowledge, called a knowledge domain. Whereas the expert system defines knowledge in terms of if-then rules, the knowledge base editor provides a curation tool where knowledge can be defined in terms of a hierarchy, attributes and facts.

Genetic Variant Curation & Pathogenicity/Severity Calculator

The American College of Medical Genetics and Genomics (ACMG) has developed standards and guidelines for assessing the likelihood that a genetic variant in a particular gene is the cause of a person’s illness. In 2015, revised guidelines were published (Richards et al, 2015), and recommend the use of specific standard terminology to describe genetic variants that cause diseases. The recommendation also describes a process for classifying variants into categories based on criteria for types of evidence (e.g. population data, computational/predictive data, functional data, segregation data and de novo data). CLIRINX has developed a web-based system for genetic variant curation that also includes a calculator for classifying genetic variants based on pathogenicity and severity. Contact us for more information.

IT & Data Management

CLIRINX provides core IT expertise to academic medical research studies, including custom software development, informatics strategy and data management. We help clients achieve their goals in medical research by providing a range of informatics and support expertise to simplify the research process and deliver client projects on time while maintaining the highest quality standards. Expertise we provide include Project Management, Software Development, Training, Informatics Strategy, Data Migration, Neuroimaging Processing, Medical Record Processing and RedCap Consultancy.

We are PMP certified by the Project Management Institute (PMI), and have years of experience managing complex IT projects across a broad range of industries. We are experts in a variety of PM methodologies, including waterfall and agile software development (and different flavors in-between). When it comes to managing your IT projects, we're considered the "safe pair of hands" to make sure your project succeeds spectacularly.


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